Statistics and R

An introduction to basic statistical concepts and R programming skills necessary for analyzing data in the life sciences.

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Created by: Michael Love

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Course Description

We will learn the basics of statistical inference in order to understand and compute p-values and confidence intervals, all while analyzing data with R. We provide R programming examples in a way that will help make the connection between concepts and implementation. Problem sets requiring R programming will be used to test understanding and ability to implement basic data analyses. We will use visualization techniques to explore new data sets and determine the most appropriate approach. We will describe robust statistical techniques as alternatives when data do not fit assumptions required by the standard approaches. By using R scripts to analyze data, you will learn the basics of conducting reproducible research.
Given the diversity in educational background of our students we have divided the series into seven parts. You can take the entire series or individual courses that interest you. If you are a statistician you should consider skipping the first two or three courses, similarly, if you are biologists you should consider skipping some of the introductory biology lectures. Note that the statistics and programming aspects of the class ramp up in difficulty relatively quickly across the first three courses. By the third course will be teaching advanced statistical concepts such as hierarchical models and by the fourth advanced software engineering skills, such as parallel computing and reproducible research concepts.
These courses make up 2 XSeries and are self-paced:
PH525.1x: Statistics and R for the Life Sciences
PH525.2x: Introduction to Linear Models and Matrix Algebra
PH525.3x: Statistical Inference and Modeling for High-throughput Experiments
PH525.4x: High-Dimensional Data Analysis
PH525.5x: Introduction to Bioconductor: annotation and analysis of genomes and genomic assays
PH525.6x: High-performance computing for reproducible genomics
PH525.7x: Case studies in functional genomics
This class was supported in part by NIH grant R25GM114818.

Intermediate Level

Time: 4 Weeks - 2-4 hours per week

Instructor Details

Michael Love

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Michael Love is Assistant Professor in the Departments of Biostatistics and Genetics at UNC Gillings School of Global Public Health. Dr. Love received his bachelor's in mathematics in 2005 from Stanford University, his master's in statistics in 2010 from Stanford University, and his Ph.D. in Computational Biology in 2013 from the Freie Universitt Berlin. Dr. Love uses statistical models to infer biologically meaningful patterns from high-throughput sequencing data, and develops open-source statistical software for the Bioconductor Project.